A 45-year-old female patient presents for an annual exam. Medical history includes 2 sisters with breast cancer, both before the age of 50. The patient reports that annual mammograms have been normal, and no masses were noted on clinical exam.
Which of the following statements is true?
- She has a higher risk of having a BRCA mutation compared with a woman with no family history of breast cancer diagnosed with breast cancer herself at age 49 years.
- Around 60% of all breast cancer are caused by BRCA mutations.
- The lifetime risk of breast cancer is higher with BRCA2 than with BRCA1 germ-line mutations.
- The cumulative risk of breast cancer in women diagnosed with a BRCA mutation is up to 70% by the age of 70 years
This question appears in Med-Challenger OBGYN Exam Review with CME
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