A 38-year-old nulliparous woman presents to discuss IVF

genetic testing (if indicated), ovarian reserve testing, uterine cavity evaluation, and semen analysis

Before beginning IVF treatment, the couple must undergo a basic evaluation that includes ovarian reserve testing, appropriate genetic testing, semen analysis, and a uterine cavity evaluation. Determining the cause of infertility in this couple may pave the way for appropriate counseling about the success rate of IVF as well as other options beyond IVF.

Ovarian reserve is important when determining the likelihood of a successful embryo, and an evaluation of the uterine cavity may reveal abnormalities that could pose difficulties during implantation. Semen analysis may help determine the method required for fertilization. Genetic testing should be performed if either partner has a family history of genetic defect. The other tests listed above may also be needed following a history and physical examination findings. Specifically, HIV testing, screening for sexually transmitted infections, and other testing, such as rubella titers and testing to rule out hepatitis B and C virus infection, are recommended--and, in some cases, required--prior to conception or may be considered part of prenatal testing.

References:

Jayaprakasan K, Hopkisson J. Assisted reproduction treatments. In: Shaw RW, et al. Gynaecology. 4th ed., 2011:312-334.

Strauss JF III, Barbieri RL. Assisted reproduction. Strauss JF III, Barbieri RL. In: Yen & Jaffe's Reproductive Endocrinology. 7th ed., 2014: 734-773.e12.